{"id":2155,"date":"2021-09-03T10:00:00","date_gmt":"2021-09-03T08:00:00","guid":{"rendered":"https:\/\/bipolar-lotse.de\/acute-vitamin-b12-supplementation-triggers-an-antidepressant-response-and-alters-the-ntrk-2-gene\/"},"modified":"2024-01-23T13:32:21","modified_gmt":"2024-01-23T12:32:21","slug":"acute-vitamin-b12-supplementation-triggers-an-antidepressant-response-and-alters-the-ntrk-2-gene","status":"publish","type":"post","link":"https:\/\/bipolar-lotse.de\/en\/acute-vitamin-b12-supplementation-triggers-an-antidepressant-response-and-alters-the-ntrk-2-gene\/","title":{"rendered":"Acute vitamin B12 supplementation triggers an antidepressant response and alters the Ntrk-2 gene"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px||||false|false&#8221;][et_pb_row _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; header_2_line_height=&#8221;1.3em&#8221; custom_padding=&#8221;5px|5px|5px|5px|false|false&#8221; text_font_size_tablet=&#8221;&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; border_width_all=&#8221;3px&#8221;]<\/p>\n<p><strong>Original title<\/strong>: Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2<\/p>\n<p><strong>Authors<\/strong>: Charlotte Trautmann, Andreas Bock, Christian A. H\u00fcbner from the Institute of Human Genetics at Jena University Hospital; Anja Urbach from the Institute of Neurology at Jena University Hospital; Olivia Engmann from the Institute of Human Genetics at Jena University Hospital and the Laboratory of Neuroepigenetics at the University of Zurich and ETH Zurich<\/p>\n<p><strong>Source<\/strong>: DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108112\">https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108112<\/a><\/p>\n<p><strong>Note<\/strong>: This scientific study is freely accessible to everyone and has been translated into German by me. The emphasis is mine.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; header_2_line_height=&#8221;1.3em&#8221; hover_enabled=&#8221;0&#8243; text_font_size_tablet=&#8221;&#8221; text_font_size_phone=&#8221;18px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>What was the study about?<\/strong><\/p>\n<p>It was investigated whether vitamin B12 supplementation has an effect on depression.<\/p>\n<p><strong>Results:<\/strong><\/p>\n<ul>\n<li>Vitamin B12 reduces DNA methylation in the Ntrk-2 gene in vitro.<\/li>\n<li>A single dose of vitamin B12 improves depression-like behavior in mice 24 hours later.<\/li>\n<li>Vitamin B12 reverses the effects of stress on the expression of the Ntrk-2 gene in the prefrontal cortex.<\/li>\n<\/ul>\n<p><strong>Summary:<\/strong><\/p>\n<ul>\n<li>Depression is the most common cause of disability worldwide. Although most research on risk factors focuses on stress, there is also a strong link between dietary factors and depression.<\/li>\n<li>Chronic vitamin B12 supplementation can reduce the risk of depression and, in animal models, help to reverse the pro-depressive effects of early childhood stress.<\/li>\n<li>However, it is still unclear whether a single acute dose of vitamin B12 is sufficient to induce antidepressant effects at the molecular or behavioral level.<\/li>\n<li>Based on pharmacological work and CRISPR-dCas9 epigenome editing in Neuro2A cells, we provide in vitro evidence for a link between vitamin B12, gene expression and DNA methylation of the antidepressant-associated gene Ntrk-2 encoding the BDNF receptor TRKB.<\/li>\n<li>Using stress induction protocols in C57Bl\/6 J mice in combination with behavioral tests and subsequent molecular tissue analysis <strong>, we provide in vivo evidence for antidepressant effects of vitamin B12<\/strong>.<\/li>\n<li>Acute supplementation with vitamin B12, but not folic acid, selectively altered DNA methylation and Ntrk-2 gene expression in vitro, although DNA methylation and Ntrk-2 gene expression do not correlate in vivo.<\/li>\n<li>Importantly, acute vitamin B12 injection improved several behavioral measures in tests of antidepressant activity while reversing the effects of chronic and acute stress on Ntrk-2 levels in vivo, although causality has not yet been established at this stage.<\/li>\n<li>Overall, acute vitamin B12 supplementation can reverse the effects of stress on Ntrk-2 gene expression and improve behaviors associated with depression-like behaviors in mice.<\/li>\n<li><strong>Our results encourage further investigation of vitamin B12 supplementation as a novel model for antidepressant action<\/strong>.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_post_nav _builder_version=&#8221;4.9.7&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|||on|||||&#8221; title_font_size=&#8221;16px&#8221;][\/et_pb_post_nav][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Original title: Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2 Authors: Charlotte Trautmann, Andreas Bock, Christian A. H\u00fcbner from the Institute of Human Genetics at Jena University Hospital; Anja Urbach from the Institute of Neurology at Jena University Hospital; Olivia Engmann from the Institute of Human Genetics at Jena University Hospital and the [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[31],"tags":[],"class_list":["post-2155","post","type-post","status-publish","format-standard","hentry","category-wiss-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Acute vitamin B12 supplementation triggers an antidepressant response and alters the Ntrk-2 gene - bipolar Lotse<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bipolar-lotse.de\/en\/acute-vitamin-b12-supplementation-triggers-an-antidepressant-response-and-alters-the-ntrk-2-gene\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Acute vitamin B12 supplementation triggers an antidepressant response and alters the Ntrk-2 gene - bipolar Lotse\" \/>\n<meta property=\"og:description\" content=\"Original title: Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2 Authors: Charlotte Trautmann, Andreas Bock, Christian A. 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